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RG-70XX

Development stage: Preclinical
Lead developer: Hangzhou Ronggu Biotechnology
Modality: CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous

Overview

RG-70XX is a preclinical-stage, dual-targeted chimeric antigen receptor natural killer (CAR-NK) cell therapy being developed by Hangzhou RonGu Biotechnology for the treatment of gastrointestinal tumors. The therapy utilizes a lentiviral vector to engineer cord blood-derived NK cells with a nanobody-based CAR construct. It is designed to target CD70 alongside a second, undisclosed target (Target X) to enhance anti-tumor efficacy and overcome potential antigen escape in gastrointestinal malignancies.

Targets

CD70 (Cluster of Differentiation 70)

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