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RG-7388 (Nova Southeastern Univ.)

Development stage: Preclinical
Lead developer: Nova Southeastern University

Overview

RG-7388 (Nova Southeastern Univ.): sourced facts only. name: "This study investigated the therapeutic efficacy of the MDM2 inhibitor (RG-7388), the dual DNMT1/G9a inhibitor (CM-272), and the DNMT inhibitor (SGI-1027) in an SK-N-AS xenograft mouse model." [DOI:10.1158/1538-7445.am2026-7066]; target: "This study investigated the therapeutic efficacy of the MDM2 inhibitor (RG-7388), the dual DNMT1/G9a inhibitor (CM-272), and the DNMT inhibitor (SGI-1027) in an SK-N-AS xenograft mouse model." [DOI:10.1158/1538-7445.am2026-7066]; developer: "Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL." [DOI:10.1158/1538-7445.am2026-7066]; stage: "Interestingly, treatment with RG-7388 also induced potent tumor suppression but exhibited a less durable response compared to CM-272." [DOI:10.1158/1538-7445.am2026-7066]

Targets

MDM2 (Mouse double minute 2 homolog)

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