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RG015

Development stage: Preclinical
Lead developer: Rigerna Therapeutics
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics

Overview

RG015 is a small interfering RNA (siRNA) therapeutic candidate under development by Rigerna Bio for the treatment of metabolic diseases. The asset utilizes a specialized delivery platform designed to specifically target adipose (fat) tissue, allowing for the localized knockdown of gene expression via RNA interference (RNAi). While the specific biological target remains undisclosed, the program aims to modulate metabolic pathways by silencing a gene involved in the pathogenesis of metabolic disorders. As of early 2024, RG015 is in the target validation stage of development.

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