rgds peptide

RGDS peptide is a synthetic tetrapeptide consisting of the amino acid sequence L-arginine, glycine, L-aspartic acid, and L-serine. It represents the minimal recognition motif found in several extracellular matrix (ECM) proteins, such as fibronectin, vitronectin, and fibrinogen, which mediates cell attachment through integrin receptors. RGDS acts as a competitive antagonist for RGD-binding integrins, including alpha-V beta-3 ($\alpha v \beta 3$), alpha-5 beta-1 ($\alpha 5 \beta 1$), and alpha-V beta-5 ($\alpha v \beta 5$). By occupying the ligand-binding pocket of these receptors, RGDS inhibits cell-matrix adhesion, cell migration, and certain forms of phagocytosis. In the context of glioblastoma research, RGDS has been utilized to block the engulfment of neutrophils by tumor cells, a process that triggers ferroptotic cell death via LC3-associated phagocytosis (LAP). By inhibiting this intercellular transfer of neutrophil contents, RGDS can prevent lipid peroxidation and subsequent tumor necrosis in glioblastoma models.

Other names

Arg-Gly-Asp-SerH-Arg-Gly-Asp-Ser-OHL-Arginyl-glycyl-L-aspartyl-L-serine