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RH5.1 + Matrix-M
- Development stage
- Phase 1
- Lead developer
- University of Oxford
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes, Liposomes → Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intramuscular
01
Overview
RH5.1 + Matrix-M is a combination vaccine candidate for the prevention of blood-stage malaria caused by Plasmodium falciparum. It consists of the recombinant protein antigen RH5.1 (a full-length soluble form of reticulocyte-binding protein homolog 5, or RH5) formulated with the saponin-based adjuvant Matrix-M to enhance immune responses[2][3][1]. The vaccine works by inducing high concentrations of anti-RH5 IgG antibodies that inhibit parasite growth in vitro and has demonstrated promising efficacy and safety in phase 2b clinical trials in African children[3][1][5]. The mechanism involves targeting the essential interaction between P. falciparum merozoites and human erythrocytes during blood-stage infection.
- Other names
- RH5.1/Matrix-MTMMatrix-M + RH5.1
02
Targets
PfRH5
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