RHA 4

RHA 4 is an **injectable dermal filler composed of resilient hyaluronic acid (HA)** crosslinked with 1,4-butanediol diglycidyl ether (BDDE), designed to mimic the natural HA found in the skin and adapt dynamically to facial movements. It is indicated for injection into the **deep dermis to superficial subcutaneous tissue** for the correction of **moderate to severe dynamic facial wrinkles and folds**, such as nasolabial folds, in adults aged 22 or older. Developed by Teoxane and marketed in the US as Revance RHA 4, this filler is formulated to preserve high molecular weight HA chains, aiming to provide durable correction and a natural look during facial expression and at rest. The manufacturing process minimizes HA degradation, resulting in a product with fewer crosslinks but greater adaptability and longevity. RHA 4 is FDA-approved and has been shown to last up to 15 months in clinical studies. Its safety and efficacy were established in prospective, randomized, split-face studies compared to other established HA fillers such as Restylane Lyft with lidocaine[1][2][3][5][6].

Brand names

RHA 4RHA4RHA-4Revance RHA 4TEOSYAL RHA 4

Other names

Resilient Hyaluronic Acid 4TEOSYAL RHA 4