Drug intelligence / Profile preview

RHA Collection

Development stage
Unknown
Lead developer
Teoxane
Modality
Recombinant Proteins and Enzymes
Administration
Intradermal, Subcutaneous, Submucosal
01

Overview

The RHA Collection is a family of injectable dermal fillers composed of resilient hyaluronic acid (RHA), designed specifically for the correction of moderate to severe dynamic facial wrinkles and folds, such as nasolabial folds. These fillers are formulated using a gentle manufacturing process that preserves the natural structure of hyaluronic acid, allowing them to more closely mimic the HA naturally found in human skin. This design enables the fillers to adapt to facial movements for a natural look both at rest and in motion. The collection includes several formulations—RHA 2, RHA 3, RHA 4, and RHA Redensity—each tailored for different depths and severities of wrinkles or volume loss. The mechanism involves providing structural support by supplementing lost or diminished hyaluronic acid in the skin’s dermal layers[3][5][6][7]. The product is FDA-approved for use in adults aged 22 years or older.

Brand names
RHA CollectionTeoxane RHA Collection
Other names
Resilient Hyaluronic Acid CollectionRHA fillers
02

Targets

CD44 (CD44 antigen)ICAM1 (Intercellular Adhesion Molecule 1)RHAMM (Hyaluronan-mediated motility receptor)

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