rhamnazin

Rhamnazin is a natural O-methylated flavonol, chemically classified as a dimethoxyflavone and structurally a methylated derivative of quercetin[1][5][9]. It is found in various plants and is noted for its antioxidant, anti-inflammatory, and anti-cancer (antineoplastic) properties[1][4][7][9]. Mechanistically, rhamnazin acts as an inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) signaling, thereby suppressing angiogenesis, tumor growth, and associated inflammation, largely through the inhibition of VEGF-induced phosphorylation of VEGFR2 and downstream signaling components such as STAT3, MAPK, and Akt[3][4][8]. Preclinical studies demonstrated anti-angiogenic and anti-tumor activity in vitro and in vivo, as well as protective, anti-inflammatory, and anti-oxidative effects in animal models for various forms of inflammation and tissue injury[3][4][6][7][9]. It is not currently marketed as a pharmaceutical drug and is best characterized as a natural compound or phytochemical with drug-like properties under preclinical investigation.

Other names

rhamnacine7,3'-dimethylquercetinrhamnacene3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxychromen-4-one