Drug intelligence / Profile preview

RHB-106

Development stage
Unknown
Lead developer
RedHill Biopharma
Modality
Small Molecules
Administration
Oral
01

Overview

RHB-106 is a proprietary, flavorless, odorless, solid oral encapsulated formulation developed for bowel preparation and cleansing of the gastrointestinal tract prior to abdominal procedures and diagnostic tests, such as colonoscopy, barium enema, or virtual colonoscopy, as well as surgical interventions like laparotomy. Its novel solid oral pill format avoids the unpleasant taste typical of current bowel preparations, aiming to improve patient compliance and outcome. The mechanism of action is as a bowel purgative, with its composition designed to induce cleansing through osmotic or laxative effects, but the exact active ingredients are undisclosed. No molecular target is described for this formulation. RHB-106 is under development, with positive results from a Phase 2a study showing significant improvement in patient response and comparable bowel cleansing efficacy[1][2][7][10].

Brand names
RHB-106RHB106RHB 106
Other names
RHB-106RHB106RHB 106
02

Targets

UGCG (UDP-glucose ceramide glucosyltransferase)SPHK2 (Sphingosine kinase 2)DEGS1 (Delta(4)-desaturase, sphingolipid 1)

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