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rhenium-188 lipid nanoparticles
- Development stage
- Preclinical
- Lead developer
- China Pharmaceutical University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Rhenium-188 lipid nanoparticles are an experimental radiopharmaceutical formulation consisting of the beta- and gamma-emitting radionuclide rhenium-188 encapsulated within lipid nanoparticles (liposomes). Developed for theranostic applications in oncology, these nanoparticles deliver localized beta radiation to tumor cells, inducing DNA double-strand breaks and cell death. In preclinical research, they have been combined with Cherenkov radiation-activated nitric oxide (NO)-releasing photosensitizers to alleviate tumor hypoxia and enhance radiosensitivity in triple-negative breast cancer (TNBC).
- Other names
- (188)Re-labeled lipid nanoparticlesrhenium-188 liposomesrhenium188 liposomesrhenium 188 liposomesrhenium-188-labeled lipid nanoparticlesrhenium188-labeled lipid nanoparticlesrhenium 188-labeled lipid nanoparticles
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