Drug intelligence / Profile preview

Rheum officinale leaf juice

Development stage: Preclinical
Modality: Small Molecules
Administration: Oral

Overview

JROL, which stands for Rheum officinale leaf juice, is a natural product derived from the leaves of the Rheum officinale plant. It exhibits antioxidant activity and is being investigated for its protective effects against dextran sulfate sodium-induced ulcerative colitis. Its mechanism of action is believed to involve the modulation of NF-κB/NLRP3 pathways and the gut microbiota.

Targets

NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)

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