Drug intelligence / Profile preview

rheum palmatum extract

Development stage
Unknown
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Rheum palmatum extract is a herbal preparation obtained from the root or rhizome of Rheum palmatum L., a plant also known as Chinese rhubarb or Turkey rhubarb. The extract contains a complex mixture of anthraquinone glycosides (such as chrysophanol-1-monoglucoside, emodin-6-monoglucoside, aloe-emodin-8-monoglucoside, physcion monoglucoside, rhein-8-monoglucoside), dianthrone glycosides (such as sennoside A-F), and free anthraquinones (including chrysophanol, emodin, physcion, aloe-emodin, rhein)[1][3][5]. These constituents are responsible for its pharmacological activities. The extract is primarily used as a **stimulant laxative** for the short-term treatment of constipation and is recognized in both traditional Chinese and modern herbal medicine[4][5][6]. Other studied pharmacological activities include anti-inflammatory, antibacterial, anti-fibrotic, and antitumor effects, as well as regulation of intestinal flora[1][2][7]. Mechanistically, the laxative and antibacterial effects are mainly attributed to the anthraquinone and dianthrone glycosides, which stimulate intestinal motility and exert direct antimicrobial actions. Rheum palmatum extract has also been shown to potentiate the activity of certain antibiotics and inhibit bacterial triggers of autoimmune inflammatory diseases[2].

Other names
Rheum palmatum root extractTurkey rhubarb extractChinese rhubarb extractDa-Huang extractrhubarb root extract
02

Targets

ATP4A (Potassium–transporting ATPase alpha chain 1)N1 NA (Influenza A neuraminidase N1)NFKB1 (NF-κB1)TP53 (Cellular Tumor Antigen p53 R175H)MAOA (Monoamine oxidase A)ATP2A (Sarcoplasmic reticulum Ca2+-ATPase)

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