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Rheum ribes root extract is a botanical extract derived from the subterranean parts of *Rheum ribes* L., a medicinal plant in the Polygonaceae family commonly found in Turkey, Iran, and Lebanon. The extract is rich in bioactive compounds including anthraquinones (such as rhein, chrysophanol, physcion, and aloe-emodin), stilbenes, tannins, and flavonoids. It is primarily investigated for its antidiabetic, hypolipidemic, and nephroprotective properties. The extract demonstrates the ability to lower blood glucose levels by stimulating pancreatic beta-cell activity and modulating intestinal glucose absorption. Furthermore, it exhibits significant cholesterol-lowering effects by inhibiting squalene epoxidase and modulating enzymes involved in bile acid metabolism. Its antioxidant properties also contribute to protecting renal tissues from oxidative damage associated with chronic diabetes.
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