Drug intelligence / Profile preview

rheum ribes root extract

Development stage
Unknown
Lead developer
Urmia University
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Rheum ribes root extract is a botanical extract derived from the subterranean parts of *Rheum ribes* L., a medicinal plant in the Polygonaceae family commonly found in Turkey, Iran, and Lebanon. The extract is rich in bioactive compounds including anthraquinones (such as rhein, chrysophanol, physcion, and aloe-emodin), stilbenes, tannins, and flavonoids. It is primarily investigated for its antidiabetic, hypolipidemic, and nephroprotective properties. The extract demonstrates the ability to lower blood glucose levels by stimulating pancreatic beta-cell activity and modulating intestinal glucose absorption. Furthermore, it exhibits significant cholesterol-lowering effects by inhibiting squalene epoxidase and modulating enzymes involved in bile acid metabolism. Its antioxidant properties also contribute to protecting renal tissues from oxidative damage associated with chronic diabetes.

Other names
Rheum ribes L. root extractrhubarb root extracthydroalcoholic extract of R. ribes rootSyrian rhubarb root extract
02

Targets

SOAT1 (Sterol O-acyltransferase)CYP7A1 (Cholesterol 7alpha-hydroxylase)SQLE (Squalene monooxygenase)

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