Drug intelligence / Profile preview

Rheumaplex

Development stage
Unknown
Lead developer
Bio-Health
Modality
Small Molecules
Administration
Oral
01

Overview

Rheumaplex is a traditional herbal medicinal product (THR) primarily used for the symptomatic relief of rheumatic pain, backache, and muscular aches. The formulation typically combines three key botanical extracts: Devil's Claw (Harpagophytum procumbens), White Willow bark (Salix alba), and Feverfew (Tanacetum parthenium). The therapeutic effects are attributed to the synergistic action of its constituents, notably iridoid glycosides (such as harpagoside) and salicylates (such as salicin). Harpagoside is known to inhibit the production of pro-inflammatory mediators by targeting the cyclooxygenase (COX) and lipoxygenase (LOX) pathways, while salicin acts as a natural precursor to salicylic acid, providing analgesic and anti-inflammatory effects through non-selective COX inhibition. Rheumaplex is marketed as a natural alternative for the management of chronic musculoskeletal conditions and is regulated as a traditional herbal medicine in jurisdictions like the United Kingdom.

Brand names
Rheumaplex
Other names
Bio-Health RheumaplexTraditional Herbal Registration 00900/0006
02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)NF-κBPTGS2 (Prostaglandin-Endoperoxide Synthase 2)ALOX5 (Arachidonate 5-lipoxygenase)

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