Drug intelligence / Profile preview

rhFGN Aα847

Development stage: Unknown
Lead developer: Novartis
Modality: Recombinant Proteins and Enzymes
Administration: Intravenous

Overview

rhFGN Aα847 is a recombinant human fibrinogen (rhFGN) variant characterized by a truncated Aα chain at residue 847. Developed by the Leiden University Medical Center (LUMC), this biologic is designed to function as a replacement for endogenous fibrinogen (Coagulation Factor I) to support hemostasis and clot formation. It is specifically being investigated for the treatment of perioperative fibrinogen deficiency and other coagulation disorders. In ex vivo clinical studies involving patients undergoing on-pump coronary artery bypass graft (CABG) surgery, rhFGN Aα847 has been evaluated for its ability to restore coagulation profiles, as measured by rotational thromboelastometry (ROTEM), in comparison to plasma-derived fibrinogen concentrates and other recombinant variants like rhFGN Aα610.

Other names: recombinant human fibrinogen Aα847 varianttruncated recombinant human fibrinogen Aα847

Targets

FXIIIa (Coagulation factor XIII A subunit)F2 (Thrombin)Fibrin (Factor Ia)

Beyond the preview

Go deeper on rhFGN Aα847.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on rhFGN Aα847.

Explore the full profile