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rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells
- Development stage
- Phase 1
- Lead developer
- City of Hope Medical Center
- Modality
- Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells are autologous CD34-positive hematopoietic progenitor cells (HPCs) that have been genetically modified using a lentiviral vector encoding three anti-HIV RNA-based inhibitors: a short hairpin RNA (shRNA) targeting HIV Tat/Rev, a TAR decoy, and a CCR5 ribozyme. This gene therapy approach aims to make the patient's immune cells resistant to HIV infection by targeting multiple stages of the viral life cycle. The modified cells are reinfused into patients following chemotherapy, particularly in the context of treating AIDS-related lymphomas.
- Other names
- Lentivirus vector rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells
02
Targets
TAR (HIV-1 TAR RNA)
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