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Rhizoma arisaematis preparata

Development stage
Preclinical
Lead developer
Obstetrics and Gynecology Hospital of Fudan University
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Vaginal
01

Overview

Rhizoma arisaematis preparata (processed Rhizoma Arisaematis, or Zhi Tian Nan Xing) is a traditional Chinese medicine preparation derived from the processed rhizomes of Arisaema species, such as *Arisaema erubescens*, *Arisaema amurense*, or *Arisaema heterophyllum*. In traditional Chinese medicine, it is used to dry dampness, resolve phlegm, and disperse swelling. It is being evaluated in clinical trials (such as ChiCTR2000033543) by the Obstetrics and Gynecology Hospital of Fudan University as a transvaginal treatment (in granule form) for persistent high-risk human papillomavirus (HPV) infection of the female genital tract. The treatment aims to promote the clearance of HPV and explore potential mechanisms related to the prevention of cervical cancer and squamous intraepithelial lesions.

Other names
processed Arisaema rhizomeprocessed Rhizoma ArisaematisTian Nan Xing (zhi)zhi Tian Nan Xing制天南星制天南星颗粒
02

Targets

IL1B (Interleukin-1 beta)ADOR (Adenosine receptors)STAT3 (Signal Transducer and Activator of Transcription 3)AcetylcholinesteraseAKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)ESR1 (ERα)

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