Drug intelligence / Profile preview

rhizoma imperatae

Development stage
Unknown
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Rhizoma Imperatae, also known as Bai Mao Gen, is the dried rhizome of the perennial grass *Imperata cylindrica*. Widely used in Traditional Chinese Medicine (TCM), it is traditionally indicated to clear heat, cool the blood, stop bleeding, and promote urination. Its chemical profile includes polysaccharides, flavonoids, triterpenoids, and organic acids. Modern pharmacological research has demonstrated anti-inflammatory, antioxidant, and hepatoprotective activities, with studies suggesting modulation of the NF-κB, TGF-β1, and TNF-α pathways. It is commonly administered as a decoction or in granule form for conditions such as hematuria, urinary tract infections, and nephrotic syndrome.

Other names
Bai Mao Gen白茅根Imperata cylindrica rhizomeCogon Grass Rhizome
02

Targets

TGFB1 (Transforming growth factor Beta-1 proprotein)TNFA (Tumor necrosis factor alpha (soluble))NF-κBPCSK9 (Proprotein convertase subtilisin/kexin type 9)

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