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rhMMP-7
- Development stage
- Preclinical
- Lead developer
- Teikoku Seiyaku
- Modality
- Therapeutic Enzymes → Recombinant Proteins and Enzymes
- Administration
- Percutaneous
01
Overview
rhMMP-7 (KTP-001) is a recombinant human matrix metalloproteinase-7 (MMP-7) being developed by Teikoku Seiyaku for the treatment of lumbar disc herniation. As a recombinant protease, rhMMP-7 is designed to be administered locally to enzymatically degrade the extracellular matrix components of the herniated nucleus pulposus, thereby reducing the size of the herniation and alleviating pressure on spinal nerves. The drug is produced using microbial manufacturing processes, with AGC Biologics serving as the contract development and manufacturing organization (CDMO) for clinical supply. It represents a non-surgical, enzymatic approach to treating degenerative disc disease.
- Other names
- recombinant human matrix metalloproteinase-7recombinant human MMP-7
02
Targets
Lipid membraneCD151 (CD151 molecule (Raph blood group))NP-ECM (Extracellular matrix components of herniated nucleus pulposus/disc tissue)SulfatideSDC2 (Syndecan-2)Matrix metalloproteinase-2 (MMP-2) and Matrix metalloproteinase-9 (MMP-9)
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