rHMPV-SHs

rHMPV-SHs is a recombinant human metapneumovirus (HMPV) challenge strain developed by the National Institute of Allergy and Infectious Diseases (NIAID). It is utilized in Phase 1 clinical trials as a controlled human infection model (CHIM) to study the natural history of HMPV infection in healthy adults and to provide a standardized platform for testing the efficacy of future HMPV vaccine candidates and antiviral therapies. The strain is a molecularly cloned version of HMPV, allowing for precise characterization and safety profiling required for inpatient isolation studies. By administering a standardized dose of the virus to healthy volunteers, researchers can monitor viral kinetics, clinical symptoms, and immune responses associated with HMPV infection, which is critical for developing preventative measures against a virus that can cause severe respiratory illness in vulnerable populations.

Other names

HMPV challenge virusrecombinant HMPV small hydrophobic genesrHMPV-SHs-National Institute of Allergy and Infectious Diseases (NIAID)-human metapneumovirus infection