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Rhodobacter sphaeroides extract
- Development stage
- Preclinical
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral, Topical
01
Overview
Rhodobacter sphaeroides extract is a biologically active preparation derived from the probiotic photosynthetic bacterium Rhodobacter sphaeroides. It is rich in carotenoids (such as ζ-carotene, neurosporene, spheroidenone, and methoxyneurosporene), amino acids (notably glycine and arginine), and other bioactive compounds. The extract has demonstrated several biological activities: - Enhances cell growth and viability more effectively than fetal bovine serum (FBS) in cell culture systems. - Reduces oxidative stress by lowering intracellular reactive oxygen species. - Stimulates lysosomal activity, supporting cellular homeostasis and autophagy. - Exhibits anti-inflammatory effects by inhibiting cytokine production (e.g., TNF-α) through mechanisms such as blocking LPS receptor recognition. - Shows protective effects against cisplatin-induced nephrotoxicity in animal models via anti-inflammatory and antioxidant actions. - Inhibits melanogenesis through modulation of the MEK/ERK signaling pathway. The product Lycogen is a commercial form of this extract with enriched carotenoid content due to genetic modification of the source strain[1][2][3][5][6][7][9].
- Brand names
- Lycogen
- Other names
- Rhodobacter sphaeroides cell-free extractR. sphaeroides extractLycogen
02
Targets
TLR4 (Toll-like receptor 4)
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