rhododendron molle extract

Rhododendron molle extract is derived from the leaves, roots, flowers, or fruits of the plant *Rhododendron molle* G. Don, a traditional Chinese medicinal herb. The extract contains a rich profile of bioactive compounds, including diterpenoids (e.g., rhodojaponin III), triterpenoids, flavonoids, and lignans. It has been recognized for its **anti-inflammatory**, **analgesic**, **antioxidant**, and **anticancer** effects, as well as for antibacterial and insecticidal activities[1][2][5]. Pharmaceutically, R. molle extract inhibits pro-inflammatory cytokines (such as TNF-α, IL-1β, IL-6), suppresses enzymes like COX-2 and iNOS, and can induce apoptosis in cancer cells and inhibit tumor cell migration[1][4][5][7]. Its primary mechanisms involve modulation of inflammatory pathways and suppression of cell proliferation. The extract has shown efficacy in preclinical models for rheumatic diseases (notably rheumatoid arthritis), hypertension, chronic bronchitis, and as an adjunct in cancer treatment, particularly against colorectal cancer cells[1][3][4]. However, the plant and its extracts contain toxic diterpenoids and should be used cautiously[1][2]. While widely used in traditional and experimental medicine, it is not an approved pharmaceutical drug in major regulatory jurisdictions.

Other names

Rhododendron molle G. Don extractRLERhododendron molle leaf extract