rhoifolin

Rhoifolin is a naturally occurring flavone glycoside (flavonoid) that functions as an inhibitor of the ALDH2-PKC delta signaling axis. In the context of chronic myeloid leukemia (CML), rhoifolin has been shown to selectively eliminate therapy-resistant leukemia stem cells (LSCs) by disrupting mitochondrial metabolic plasticity and oxidative phosphorylation. By targeting the ALDH2-PKC delta hub, it promotes mitophagy and increases chemosensitivity, potentially working in synergy with tyrosine kinase inhibitors (TKIs) to eradicate minimal residual disease (MRD) and prevent disease relapse.

Other names

apigenin 7-O-neohesperidosideapigenin7-O-neohesperidosideapigenin-7-O-neohesperidoside