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Drug intelligence / Profile preview
rHSC-DIPGVax
- Development stage
- Phase 1
- Lead developer
- Agenus
- Modality
- Vaccines & Immunotherapeutics, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Recombinant Proteins and Enzymes, Peptides
- Administration
- Subcutaneous
01
Overview
rHSC-DIPGVax is an off-the-shelf neo-antigen heat shock protein (HSP) vaccine containing 16 peptides that reflect neo-epitopes found in the majority of diffuse intrinsic pontine glioma (DIPG) and diffuse midline glioma (DMG) tumors. The vaccine is designed to stimulate the patient's immune system to recognize and attack tumor cells by presenting tumor-specific antigens. It is being investigated in combination with checkpoint inhibitors such as balstilimab (anti-PD-1 antibody) and zalifrelimab (anti-CTLA-4 antibody). The primary indication is for newly diagnosed pediatric patients with DIPG or DMG who have completed radiation therapy[2][3][6].
02
Targets
LRP1 (Prolow-density lipoprotein receptor-related protein 1)OLR1 (Lectin-like oxidized LDL receptor-1)SCARF1 (Scavenger receptor class F member 1)
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