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The **rhubarb n-butanol extract** is a polar fraction derived from the rhizome of rhubarb (Rheum species) using n-butanol as a solvent in the extraction process. This extract is particularly enriched in phenolic and polyphenolic compounds, with established antioxidant properties, as demonstrated by strong DPPH and ABTS radical scavenging activities. Compared to aqueous and ethyl acetate extracts, the n-butanol extract of rhubarb contains moderate to high levels of total polyphenols and exhibits significant in vitro antioxidant activity[2]. In comparative animal models, n-butanol rhubarb extract did not promote hepatotoxicity or liver injury in a rat model of DEN-induced liver cancer, in contrast with the aqueous rhubarb extract[1][3][4].
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