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rhubarb powder
- Development stage
- Phase 1
- Lead developer
- Union Hospital
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Rhubarb powder is a botanical preparation derived from the dried roots and rhizomes of *Rheum* species, such as *Rheum palmatum* or *Rheum officinale* (commonly known as Dahuang in Traditional Chinese Medicine). It contains active anthraquinones (such as emodin, rhein, and aloe-emodin) and tannins, which exert laxative, anti-inflammatory, and antibacterial effects. In clinical trials, such as those conducted by the Union Hospital of Tongji Medical College, rhubarb powder is being evaluated for its potential to reduce intestinal bacterial translocation, systemic inflammation, and endotoxemia in patients with decompensated cirrhosis.
- Other names
- Dahuang powderRheum officinale powderRheum palmatum powderrhubarb root powderTurkey rhubarb powder
02
Targets
AQP3 (Aquaporin-3 channel protein)CYP1B1 (Cytochrome P450 1B1)DPP-4 (Dipeptidyl Peptidase-IV)HTR4 (5-Hydroxytryptamine receptor 4)KIT (c-KIT proto-oncogene receptor tyrosine kinase)TLR2 (Toll-like Receptor 2)TLR4 (Toll-like receptor 4)
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