ribavirin monophosphate

Ribavirin monophosphate is the phosphorylated metabolite of the antiviral drug ribavirin. It is a synthetic guanosine nucleoside analog that acts as a competitive inhibitor of inosine 5′-monophosphate dehydrogenase (IMPDH), mimicking inosine 5′-monophosphate. This inhibition disrupts de novo synthesis of guanine nucleotides and decreases intracellular GTP pools, leading to reduced viral protein synthesis and limited replication of viral genomes[1][4]. Ribavirin itself is used as an antiviral agent against several RNA and DNA viruses—primarily hepatitis C virus (in combination with interferon) and certain viral hemorrhagic fevers[1][2][4]. Ribavirin monophosphate is not administered directly as a drug but represents an active intermediate in the metabolic pathway of orally or parenterally administered ribavirin.

Other names

ribavirin monophosphatevirazole 5'-phosphateribavirin-5'-phosphateribavirin 5'-monophosphate