Drug intelligence / Profile preview

Rick Simpson Oil

Development stage
Preclinical
Lead developer
Rick Simpson
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical, Sublingual
01

Overview

Rick Simpson Oil (RSO) is a high-potency, full-spectrum cannabis extract characterized by exceptionally high concentrations of tetrahydrocannabinol (THC). Developed by Canadian activist Rick Simpson, the oil is produced by washing cannabis buds with a solvent (such as grain alcohol or ethanol) to extract cannabinoids, terpenes, and other plant compounds, followed by the evaporation of the solvent to leave a thick, viscous, and dark-colored oil. RSO acts primarily as an agonist at the Cannabinoid receptor 1 (CB1) and Cannabinoid receptor 2 (CB2) within the endocannabinoid system. While it is widely used in alternative medicine for conditions such as basal cell carcinoma, chronic pain, epilepsy, and multiple sclerosis, it is not an FDA-approved pharmaceutical drug and lacks standardized clinical evidence to support its therapeutic claims. It is typically available through cannabis dispensaries in jurisdictions where medical or recreational marijuana is legal.

Other names
RSOPhoenix Tears
02

Targets

CNR1 (Cannabinoid receptor 1)

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