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Ricrolin TE
- Development stage
- Unknown
- Lead developer
- Sooft Italia
- Modality
- Small Molecules
- Administration
- Ophthalmic
01
Overview
**Ricrolin TE** is a proprietary ophthalmic riboflavin formulation developed by Sooft Italia for transepithelial corneal collagen cross-linking in progressive keratoconus. The solution contains riboflavin 0.1% with dextran 15%, trometamol, and EDTA; trometamol and EDTA enhance riboflavin penetration through intact corneal epithelium. Following topical loading, UV-A irradiation activates riboflavin as a photosensitizer, generating collagen cross-links within the corneal stroma to increase biomechanical rigidity and reduce ectatic progression. Ricrolin TE is used as part of an epithelium-on CXL procedure rather than as a standalone pharmacological treatment. ([sciencedirect.com](https://www.sciencedirect.com/science/article/pii/S0886335012002945))
- Brand names
- Ricrolin TE
02
Targets
COL (Collagen type XXI alpha 1 chain)
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