Drug intelligence / Profile preview

ridogrel

Development stage
Unknown
Lead developer
Janssen Pharmaceutica
Modality
Small Molecules
Administration
Intravenous, Oral
01

Overview

Ridogrel is a dual-action small molecule drug that acts as both a thromboxane A2 synthase inhibitor and a thromboxane A2/prostaglandin endoperoxide receptor antagonist. It was developed for the prevention of systemic thromboembolism and as an adjunctive agent to thrombolytic therapy in acute myocardial infarction. By inhibiting the synthesis of thromboxane (a potent vasoconstrictor and promoter of platelet aggregation) and blocking its receptor, ridogrel reduces blood clot formation, accelerates recanalization, and may delay or prevent reocclusion during systemic thrombolysis. Although it is more potent than aspirin in some antiplatelet effects, clinical trials have not demonstrated superiority over aspirin for improving outcomes in acute myocardial infarction patients[1][2][3][4][6].

Other names
RidogrelumRidogrelum [INN-Latin]110140-89-1
02

Targets

TBXAS1 (Thromboxane A2 synthase)TYMP (Thymidine phosphorylase)

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