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rimonabant + paracetamol
- Development stage
- Discontinued
- Lead developer
- Sanofi
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Rectal
01
Overview
Rimonabant + paracetamol is a hypothetical or research combination of two small molecule drugs, each with distinct mechanisms of action. Rimonabant is an anorectic anti-obesity drug that acts as an inverse agonist at the cannabinoid CB1 receptor and also antagonizes the μ-opioid receptor. It was developed for weight loss and metabolic syndrome but withdrawn due to psychiatric side effects[1][2][5]. Paracetamol (also known as acetaminophen) is a widely used analgesic and antipyretic agent, whose mechanism involves central inhibition of prostaglandin synthesis and modulation of endocannabinoid signaling pathways[3][4]. There are no approved pharmaceutical products or clinical evidence supporting the use of this specific combination in medical practice.
- Other names
- acetaminophen + rimonabant
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)CNR1 (Cannabinoid receptor 1)MOR (Mu opioid receptor)
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