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rintatolimod + interferon alfa-2b + celecoxib
- Development stage
- Unknown
- Lead developer
- AIM ImmunoTech
- Modality
- Small Molecules, RNA Therapeutics → Nucleic Acid Therapeutics, Cytokines & Interferons → Recombinant Proteins and Enzymes
- Administration
- Intravenous, Oral, Subcutaneous
01
Overview
The Chemokine Modulatory Regimen (CKM) is an investigational combination immunotherapy consisting of rintatolimod (a selective TLR3 agonist), interferon alfa-2b (a cytokine), and celecoxib (a COX-2 inhibitor). Developed at Roswell Park Comprehensive Cancer Center, the regimen is designed to reprogram the tumor microenvironment by inducing the production of T-cell-attracting chemokines such as CXCL9, CXCL10, and CCL5. This process aims to convert immunologically "cold" tumors into "hot" tumors by increasing the infiltration of cytotoxic T lymphocytes (CTLs), thereby enhancing the efficacy of other immunotherapies or the body's natural anti-tumor response. It has been primarily evaluated in Phase 1 and Phase 2 clinical trials for colorectal cancer, breast cancer, and melanoma.
- Other names
- Chemokine Modulatory RegimenCKM regimen
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)IFNAR (Immune system modulation via type I interferon receptor)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TLR3 (Toll-like receptor 3)
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