risedronate + calcium

Risedronate + calcium is a combination pharmaceutical regimen used for the prevention and treatment of osteoporosis, especially in postmenopausal women and individuals with steroid-induced osteoporosis[1][3]. The combination consists of risedronate (a bisphosphonate) and calcium carbonate, typically administered as a weekly cycle with 1 risedronate tablet and 6 calcium tablets. - **Mechanism of Action:** Risedronate inhibits bone resorption by osteoclasts through direct binding to bone hydroxyapatite and inhibition of farnesyl pyrophosphate synthase, leading to osteoclast apoptosis and reduced bone breakdown[1][3][4]. Calcium carbonate is essential for bone formation and maintenance and helps to prevent calcium deficiency[1][3]. - **Primary Indication:** The regimen is used in osteoporosis (postmenopausal, steroid-induced), and may also be used for Paget's disease of bone and to reverse progression of osteoporosis[1][3]. - **Prescription Status:** Approved combination, available only with prescription[3].

Brand names

Actonel Combi

Other names

risedronic acid + calcium carbonatecalcium carbonate + risedronate