Drug intelligence / Profile preview

Risperdal Consta

Development stage
Approved
Lead developer
Johnson & Johnson
Modality
Device-based Delivery → Drug Delivery Systems
Administration
Intramuscular
01

Overview

Risperdal Consta is a long-acting injectable formulation of risperidone, an atypical antipsychotic medication. It's administered as an intramuscular injection every two weeks and is used primarily for the treatment of schizophrenia and as maintenance therapy for Bipolar I Disorder. Risperdal Consta contains risperidone in a prolonged-release suspension that provides consistent medication delivery over a two-week period. It's available in multiple dosage strengths: 12.5 mg, 25 mg, 37.5 mg, and 50 mg. The medication is administered by healthcare professionals via deep intramuscular injection in either the deltoid (using a 1-inch needle) or gluteal muscle (using a 2-inch needle), with injection sites alternated between administrations. When starting treatment with Risperdal Consta, oral risperidone (or another antipsychotic medication) should be given with the first injection and continued for 3 weeks. This is necessary because the main release of risperidone from the injection site begins around 3 weeks after administration.

Brand names
Risperdal Consta
Other names
risperidone long-acting injectionrisperidone sustained release microsphererisperidone PLGA microspheres
02

Targets

ADRA1A (α1A)ADRA2A (α2A)DRD1 (Dopamine D1 Receptor)DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)DRD4 (Dopamine D4 Receptor)HRH1 (Histamine H1 Receptor)M1 (Muscarinic acetylcholine receptor M1)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2C (5-hydroxytryptamine 2C receptor)HTR1D (5-hydroxytryptamine receptor 1D)HTR2A (Serotonin receptor 5-HT2A)

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