Drug intelligence / Profile preview

risperidone implant

Development stage
Discontinued
Lead developer
Delpor
Modality
Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules
Administration
Subcutaneous, Intradermal
01

Overview

Risperidone implant refers to investigational subcutaneous or intradermal implants designed for the long-term delivery of risperidone, an atypical antipsychotic. These implants are intended to provide sustained therapeutic plasma levels of risperidone over extended periods (ranging from 3 months up to 12 months) for the maintenance treatment of schizophrenia. The mechanism of action is via antagonism at dopamine D2 receptors and serotonin 5-HT2A receptors in the brain. Multiple formulations have been developed by different companies using various technologies such as polymer-based matrices or titanium cylinders with proprietary drug release systems[1][4][5]. The goal is to improve medication adherence and reduce relapse rates compared to oral or injectable depot formulations.

Other names
risperidone subcutaneous implantrisperidone controlled-release implantRI
02

Targets

HTR2A (Serotonin receptor 5-HT2A)DRD2 (Dopamine D2 Receptor)

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