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rituximab + methotrexate + temozolomide + thiotepa
- Development stage
- Phase 2
- Lead developer
- Biogen
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
A combination chemotherapy regimen consisting of rituximab (anti-CD20 monoclonal antibody), high-dose methotrexate (antimetabolite), temozolomide (alkylating agent), and thiotepa (alkylating agent). This regimen is primarily used in the treatment of primary central nervous system lymphoma (PCNSL) and other malignant brain tumors. The combination has shown promising response rates and improved progression-free survival compared to regimens without rituximab.
- Other names
- MRTRMT
02
Targets
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