Drug intelligence / Profile preview

RIVAL-02

Development stage
Preclinical
Lead developer
Turnstone Biologics
Modality
Oncolytic Viruses → Oncolytic Therapeutics, Peptides, Nanoparticles → Drug Delivery Systems
01

Overview

**RIVAL-02** is a Turnstone Biologics preclinical oncology program directed at **human papillomavirus antigens** in HPV-positive tumors. Turnstone's pipeline described complementary therapeutic approaches including an engineered oncolytic vaccinia virus platform, peptide nanoparticle approaches, and rhabdovirus-based approaches. The intended mechanism is to generate HPV antigen-directed antitumor immune responses while oncolytic viral modalities may also promote tumor-cell lysis and immunogenic remodeling of the tumor microenvironment.

Other names
RIVAL-2RIVAL2RIVAL 2
02

Targets

HPV16 E7 (Human papillomavirus 16 E7 protein)

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