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**RIVAL-02** is a Turnstone Biologics preclinical oncology program directed at **human papillomavirus antigens** in HPV-positive tumors. Turnstone's pipeline described complementary therapeutic approaches including an engineered oncolytic vaccinia virus platform, peptide nanoparticle approaches, and rhabdovirus-based approaches. The intended mechanism is to generate HPV antigen-directed antitumor immune responses while oncolytic viral modalities may also promote tumor-cell lysis and immunogenic remodeling of the tumor microenvironment.
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