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RJ4960 is a small molecule inhibitor of Spleen Tyrosine Kinase (SYK) currently in early-stage development by Nanjing Ruijie Pharma. SYK is a non-receptor cytoplasmic tyrosine kinase that plays a critical role in signaling from various immune receptors, including B-cell receptors (BCR) and Fc receptors. By inhibiting SYK, RJ4960 aims to modulate immune responses, potentially for the treatment of autoimmune diseases or hematological malignancies, although its specific indications remain undisclosed by the developer.
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