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RJVA-001
- Development stage
- Preclinical
- Lead developer
- Fractyl Health
- Modality
- Gene Therapies
- Administration
- Intra-pancreatic
01
Overview
RJVA-001 is a preclinical gene therapy candidate developed by Fractyl Health for the treatment of type 2 diabetes and obesity. As the lead candidate of the Rejuva platform, it utilizes an adeno-associated virus (AAV) vector to deliver a transgene encoding a potent glucagon-like peptide-1 (GLP-1) analog directly to the pancreas. The therapy is designed to provide sustained, endogenous production of GLP-1 within the pancreatic islets, potentially offering a long-acting alternative to daily or weekly GLP-1 receptor agonist injections. It is delivered via a proprietary endoscopic procedure aimed at localizing the therapy to the target tissue to improve glycemic control and promote weight loss.
- Brand names
- Rejuva Smart GLP-1
- Other names
- Rejuva Smart GLP-1RJVA-001RJVA001RJVA 001Rejuva gene therapy platform
02
Targets
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