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RM-LNC
- Development stage
- Preclinical
- Lead developer
- UCLouvain
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Oral
01
Overview
RM-LNC (Rhein-Modified Lipid Nanocapsules) is an experimental oral drug delivery nanosystem designed to enhance the treatment of type 2 diabetes and associated metabolic disorders such as hepatic steatosis. The system consists of lipid nanocapsules modified with rhein, a natural anthraquinone derivative. Rhein serves a dual functional role: it acts as a ligand to improve the intestinal absorption and bioavailability of encapsulated therapeutic peptides (such as GLP-1 or its analogs) and independently stimulates the endogenous secretion of glucagon-like peptide-1 (GLP-1) from enteroendocrine L-cells. By combining the protective encapsulation of peptides with the secretagogue effect of rhein, RM-LNC aims to overcome the biological barriers to oral peptide delivery while providing synergistic glucose-lowering effects.
- Other names
- Rhein-modified lipid nanocapsulesRhein-loaded lipid nanocapsules
02
Targets
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