Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
RN5681
- Development stage
- Phase 1
- Lead developer
- Rona Therapeutics
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Subcutaneous
01
Overview
**RN5681** is an investigational GalNAc-conjugated, dual-targeting small interfering RNA designed by Rona Therapeutics to silence hepatic expression of **proprotein convertase subtilisin/kexin type 9** and **lipoprotein(a)**. The single molecular entity is intended to concurrently lower low-density lipoprotein cholesterol through PCSK9 suppression and lower lipoprotein(a) through LPA silencing, thereby addressing complementary drivers of residual atherosclerotic cardiovascular risk. RN5681 entered Phase 1 clinical evaluation in a randomized, placebo-controlled single-ascending-dose study in healthy adults with elevated lipid parameters. ([ronatherapeutics.com](https://www.ronatherapeutics.com/news/43))
- Other names
- PCSK9/LPA bispecific siRNAPCSK9-LPA bispecific siRNAPCSK-9-LPA bispecific siRNAPCSK 9-LPA bispecific siRNAPCSK9-LPA dual-targeting siRNAPCSK-9-LPA dual-targeting siRNAPCSK 9-LPA dual-targeting siRNA
02
Targets
LPA (Lysophosphatidic acid)PCSK9 (Proprotein convertase subtilisin/kexin type 9)
Beyond the preview
Go deeper on RN5681.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on RN5681.