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Drug intelligence / Profile preview
RNA-lipoplex prostate cancer vaccine
- Development stage
- Unknown
- Lead developer
- BioNTech
- Modality
- Vaccines & Immunotherapeutics, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
The RNA-lipoplex prostate cancer vaccine is an investigational mRNA-based immunotherapy developed by Ahvaz Jundishapur University of Medical Sciences. It utilizes an RNA-lipoplex (liposome) delivery system for intravenous administration, encoding three specific prostate cancer-associated antigens: prostatic acid phosphatase (PAP), prostate-specific membrane antigen (PSMA), and six-transmembrane epithelial antigen of the prostate 1 (STEAP1). The vaccine is designed to stimulate a systemic T-cell-mediated immune response against tumor cells expressing these antigens. It is currently being evaluated in Phase I clinical trials for the treatment of prostate cancer.
- Other names
- RNA-liposome prostate cancer vaccine
02
Targets
P fimbriaePSMA (Prostate-specific membrane antigen)STEAP1 (Six-transmembrane epithelial antigen of prostate 1)PAP (Prostatic acid phosphatase)
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