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RNK001
- Development stage
- Unknown
- Lead developer
- Radboud University Medical Center
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
RNK001 is an allogeneic natural killer (NK) cell therapy generated ex vivo from umbilical cord blood-derived CD34+ hematopoietic stem and progenitor cells (HSPC). Developed by Radboud University Medical Center, the manufacturing process utilizes a combination of interleukin-15 (IL-15), interleukin-12 (IL-12), and the aryl hydrocarbon receptor (AhR) antagonist StemRegenin-1 (SR1) to produce a highly pure and functional NK cell product. RNK001 is primarily investigated for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), where it aims to provide an anti-tumor response through the infusion of mature, activated NK cells expressing receptors such as NKG2D, DNAM-1, and natural cytotoxicity receptors (NCRs).
- Other names
- HSPC-NK cellsCD34+ progenitor-derived NK cells
02
Targets
NCR2 (Natural cytotoxicity triggering receptor 2)NCR3 (Natural cytotoxicity trigger receptor 3 (NKp30))NCR1 (Natural cytotoxicity triggering receptor 1)NKG2D (Natural killer group 2 member D receptor)CD226 (DNAX accessory molecule 1)
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