Drug intelligence / Profile preview

ro 12-7310

Development stage
Preclinical
Lead developer
Roche
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
01

Overview

Ro 12-7310 is a synthetic retinoid compound, also known as demethyletretin. It is structurally related to other retinoids and has been studied primarily as an experimental drug. Ro 12-7310 acts by inhibiting the release of arachidonic acid, which may impact inflammatory pathways[2][9]. It binds with high affinity to cellular retinoic acid binding proteins (CRABPs), suggesting it mimics or modulates endogenous retinoid signaling in cells[5]. Retinoids are known for their roles in regulating cell growth, differentiation, and keratinocyte biology; thus, Ro 12-7310 has been investigated for its effects on keratinocyte differentiation and potential dermatological applications[10]. The compound remains experimental and is not approved for clinical use.

Other names
demethyletretin
02

Targets

CRABP2 (Cellular retinoic acid-binding protein 2)

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