ro4368554

**Ro4368554** is a selective antagonist of the **5-HT6 receptor** (Serotonin 6 receptor) developed primarily for central nervous system indications such as memory disorders and schizophrenia-related deficits[1][3][5]. It is a **small molecule drug** demonstrating high brain penetration (80–110%) and has shown efficacy in preclinical models for reversing memory deficits induced by cholinergic and serotonergic disruption[5]. Ro4368554 was also effective in modulating sensory gating and emotional learning, including reversal of prepulse inhibition and fear conditioning deficits in animal studies, which are sensitive to dysfunctions found in schizophrenia[3]. The drug was originally developed by **Roche** and was last reported to be in the preclinical phase for memory disorders[1].

Other names

Ro 4368554Ro4368554Ro-4368554