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RO5285119 + fluoxetine
- Development stage
- Phase 1
- Lead developer
- Roche
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
RO5285119 + fluoxetine is a **combination of two pharmaceuticals:** RO5285119 (also known as balovaptan), a small molecule vasopressin V1a receptor antagonist developed primarily for autism spectrum disorder, and fluoxetine, a selective serotonin reuptake inhibitor (SSRI) widely used for depression, anxiety disorders, and other psychiatric conditions. RO5285119 (balovaptan) acts as a vasopressin V1a receptor antagonist and modulates social behavior pathways in the brain, while fluoxetine increases serotonergic neurotransmission by inhibiting serotonin reuptake. There is no evidence of a marketed fixed-dose or co-packaged product containing this exact combination, nor specific clinical development for the combination beyond their individual uses.
- Other names
- balovaptan + fluoxetine
02
Targets
SERT (Sodium-dependent serotonin transporter)AVPR1A (Arginine vasopressin receptor 1A)
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