Drug intelligence / Profile preview

Robitussin

Development stage
Unknown
Lead developer
HALEON
Modality
Small Molecules
Administration
Oral
01

Overview

Robitussin is a prominent brand of over-the-counter (OTC) cough and cold medications developed and marketed by Haleon. The product line is designed to treat various symptoms of the common cold and upper respiratory infections, primarily focusing on cough suppression and chest congestion relief. The brand features several formulations, including daytime and nighttime syrups. The daytime variants, such as Robitussin Maximum Strength DM, typically combine **dextromethorphan hydrobromide** (an antitussive) with **guaifenesin** (an expectorant). The nighttime variants, such as Robitussin Maximum Strength Nighttime DM, combine dextromethorphan with **doxylamine succinate**, a first-generation antihistamine that provides relief from runny nose and sneezing while also acting as a sedative. Haleon has conducted real-world evidence studies (e.g., NCT06716645) to evaluate the impact of these multi-symptom relief regimens on the health-related quality of life in adults with cough associated with the common cold.

Brand names
RobitussinRobitussin Maximum Strength Cough and Chest Congestion DMRobitussin Maximum Strength Nighttime Cough DM
Other names
Robitussin Maximum Strength DMRobitussin Maximum Strength Nighttime DM
02

Targets

NMDAR (Glutamate receptor ionotropic, NMDA)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)SIGMAR1 (Sigma non-opioid intracellular receptor 1)HRH1 (Histamine H1 Receptor)

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