rocuronium + sugammadex (Hospital Kuala Lumpur)

The term **deep neuromuscular blockade-Kuala Lumpur General Hospital** refers to a specific pharmacological protocol used in clinical trials to achieve and reverse a profound state of muscle relaxation during surgery. This regimen involves the administration of **rocuronium bromide**, a non-depolarizing neuromuscular blocking agent (NMBA), to maintain a deep level of paralysis characterized by a Post Tetanic Count (PTC) of 1-2. Rocuronium acts as a competitive antagonist at nicotinic acetylcholine receptors at the neuromuscular junction. Following the surgical procedure, the blockade is rapidly reversed using **sugammadex**, a modified gamma-cyclodextrin that acts as a selective relaxant binding agent. Sugammadex encapsulates rocuronium molecules in the plasma, preventing them from binding to receptors and facilitating rapid recovery of muscle function. This specific protocol was evaluated by the Kuala Lumpur General Hospital to compare surgical conditions and patient satisfaction against moderate neuromuscular blockade in women undergoing laparoscopic gynecological surgeries.

Other names

Deep neuromuscular blockadeDeep NMBdeep neuromuscular blockade-Kuala Lumpur General Hospital