Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
roemerine
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral, Intraperitoneal
01
Overview
Roemerine is a natural aporphine alkaloid primarily isolated from the leaves of *Nelumbo nucifera* (Sacred Lotus) and other plants. It is extensively researched for its potent antineoplastic and antimicrobial properties. In the context of oncology, roemerine has demonstrated significant anti-prostate cancer effects by inhibiting cell proliferation and inducing apoptosis in various cell lines, including DU145, LNCaP, and PC-3, as well as reducing tumor growth in mouse models. Its mechanism of action involves the inhibition of the PI3K/Akt signaling pathway and potential DNA intercalation. Additionally, roemerine acts as an antimicrobial agent by functioning as an efflux pump inhibitor, which can help reverse multidrug resistance in pathogens such as *Staphylococcus aureus*.
- Other names
- (-)-roemerineroemerin1,2-methylenedioxy-6-methylaporphine
02
Targets
HTR2A (Serotonin receptor 5-HT2A)HTR2B (5-Hydroxytryptamine Receptor 2B)HTR2C (5-hydroxytryptamine 2C receptor)ADRA1A (α1A)DNAPI3K (Phosphoinositide-3-kinase regulatory subunit 6)AKT (RAC-alpha serine/threonine-protein kinase)
Beyond the preview
Go deeper on roemerine.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on roemerine.