Drug intelligence / Profile preview

Rohto Cooling Eye Drops

Development stage
Unknown
Lead developer
Rohto Pharmaceutical
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

Rohto Cooling Eye Drops (marketed as Rohto Cool Relief) is an over-the-counter ophthalmic formulation manufactured by The Mentholatum Company, a subsidiary of Rohto Pharmaceutical. The product contains two active ingredients: naphazoline hydrochloride (0.012%) and polysorbate 80 (0.2%). Naphazoline hydrochloride is a small molecule vasoconstrictor that acts as an alpha-adrenergic agonist, constricting blood vessels in the eye to reduce redness. Polysorbate 80 serves as a lubricant to provide relief from dryness and irritation. The formulation also features "CoolSense Technology," which incorporates menthol as an inactive ingredient to deliver a characteristic cooling sensation. It is indicated for the temporary relief of red, dry, and irritated eyes for up to 8 hours.

Brand names
Rohto Cooling Eye DropsRohto Cool Relief
02

Targets

ADRA1A (α1A)

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